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At least 14 days ought to transpire in between discontinuation of an MAOI intended to treat psychological ailments and also initiation of treatment with Anafranil. Alternatively, a minimum of 14 days need to be permitted after quiting Anafranil before starting an MAOI intended to treat psychological conditions (view CONTRAINDICATIONS).





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Do not begin Anafranil in a patient which is being treated with linezolid or intravenous methylene blue since there is enhanced risk of serotonin syndrome. In an individual that calls for more immediate therapy of a psychiatric problem, various other treatments, including hospitalization, should be taken into consideration (view CONTRAINDICATIONS).





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In many cases, a patient currently getting Anafranil therapy could require urgent therapy with linezolid or intravenous methylene blue. If appropriate choices to linezolid or intravenous methylene blue therapy are not readily available as well as the possible benefits of linezolid or intravenous methylene blue therapy are judged to exceed the dangers of serotonin disorder in a particular client, Anafranil should be quit without delay, and also linezolid or intravenous methylene blue can be carried out. The individual must be kept an eye on for signs of serotonin disorder for two weeks or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever precedes. Therapy with Anafranil might be resumed 24 hours after the last dose of linezolid or intravenous methylene blue (view WARNINGS).

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